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KMID : 0861020010160010029
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Korea Journal of Herbology
2001 Volume.16 No. 1 p.29 ~ p.40
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Antioxidative activity of Sihosamultang Methanol Extract
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Abstract
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Sihosamultang has been used in treatment for puerperal fever, liver disease in traditional medicine. The present study was carried out to evaluate the antioxidant effects of Sihosamultang methnol extract(SME) in vitro. The inhibitory effect of SME on lipid peroxidation was examined in the linoleic acid autoxidation system. In this test, SME significantly inhibited the time course of the lipid peroxidation. And SME showed about 77% scavenging effect on DPPH radical, also exhibited about 89% inhibitory effect on lipid peroxide formation induced by hydroxyl radical derived from H₂O₂-Fe^2+ in the rat liver homogenate. And SME dose-dependently inhibited superoxide generation from xanthine-xanthine oxidase system. In addition, SME protected the hepatic cell death induced by tert-butyl hydroperoxide. These data indicated that SME might play a protective role against oxidative injury by free radicals.
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